Principal Engineer, Cloud Ops

JOB SUMMARY

We are seeking a talented and motivated Cloud Ops Engineer to join the tightly integrated technology and drug discovery operation at Iambic Therapeutics. You will work in the Software organization and work closely with the ML organization to help drive the Cloud Ops Roadmap, leading and supporting delivery of the roadmap goals for projects across the organization. You will work with teams developing and deploying Iambic’s drug discovery platform, Computational Science applications and Machine Learning models. You will also help deliver and support ISO 27001 compliant Cloud Ops processes.

This role is preferably Hybrid in Boston, then East Coast, San Diego, or Remote (with workspace support).

KEY RESPONSIBILITIES

- Support and contribute to the Cloud Ops roadmap, aligning infrastructure initiatives with business priorities.

- Provide technical leadership and drive architecture decisions across platform and infrastructure teams.

- Lead the design and evolution of scalable, highly available AWS cloud infrastructure.

- Build and operate production systems with a strong focus on reliability, performance, and cost efficiency.

- Design and manage cloud networking (VPN, VPC, routing, DNS, load balancing, secure connectivity).

- Implement Infrastructure as Code (Terraform) and automate provisioning and operations.

- Troubleshoot complex issues across distributed systems, including networking and performance bottlenecks.

- Apply security best practices and support the ISO 27001 compliance frameworks.

- Improve observability, CI/CD pipelines, and overall operational maturity.

- Mentor engineers in Cloud Services and influence Cloud Ops best practices across the org.

QUALIFICATIONS

- Minimum of 12 years of related experience with a bachelor’s degree; or 10 years and a master’s degree; or equivalent experience.

- Strong understanding of CI/CD pipelines.

- Strong Infrastructure as Code skills – for example in Docker, Packer/Ansibl...