Principal Scientist, Vector Biology

Legend Biotech is seeking a Principal Scientist to join the Vector Biology Upstream team in Philadelphia, focusing on early process development and establishing a manufacturable lentiviral vector (LVV) platform to support in-vivo CAR-T programs. This role is integral to the company's mission of developing advanced cell therapies for life-threatening diseases.

The Principal Scientist will lead the early-stage definition, interrogation, and optimization of upstream LVV processes, from molecular construct design through scalable bioreactor manufacturing. Responsibilities include establishing and optimizing seed train strategies, evaluating LVV constructs, designing production workflows, conducting media optimization, and collaborating with downstream colleagues to ensure a cohesive, end-to-end manufacturable process.

Candidates must possess a Ph.D. in Molecular Biology, Biochemical Engineering, or a related field, with at least 8 years of experience in viral vector process development. Expertise in molecular biology, bioprocess engineering, and scalable bioreactor manufacturing is essential. Strong analytical skills, problem-solving abilities, and experience in cross-functional collaboration are also required.

Legend Biotech offers a competitive compensation package, including a comprehensive benefits plan with health insurance, retirement savings options, and professional development opportunities. Employees are encouraged to engage in continuous learning and career advancement within the organization.

The company fosters a collaborative and innovative work environment, emphasizing teamwork and scientific excellence. Joining Legend Biotech provides an opportunity to contribute to cutting-edge research and development in cell therapy, with significant potential for professional growth and impact in the field.