Research Scientist I/II, Bioanalytical Sciences & Assay Development
JOB SUMMARY
We are seeking a highly motivated Research Scientist, Bioanalytical Sciences & Assay Development to join our drug discovery team. This scientist will develop and implement mass spectrometry-based assays and bioanalytical workflows supporting Hit Identification (HitID), ADME/DMPK characterization, and physicochemical property assessment. A key focus will be the development and application of MS-based screening approaches for HitID, including Affinity Selection Mass Spectrometry (ASMS) and other MS-based capabilities.
The ideal candidate will have a strong foundation in bioanalytical science, mass spectrometry, and assay development, with the ability to develop robust and scalable assays for small-molecule drug discovery. This scientist will work at the interface of experimental science, automation, and AI-driven molecular design, generating high-quality data that inform compound optimization and enable rapid design–make–test–learn cycles. This position will be based in our San Diego Headquarters.
KEY RESPONSIBILITIES
- Develop and implement MS-based assays and screening workflows for HitID, including ASMS and other MS-based approaches.
- Develop fit-for-purpose bioanalytical and biochemical assays supporting screening, hit confirmation, and compound characterization.
- Develop and execute in vitro ADME/DMPK assays, including metabolic stability, permeability, protein binding, and related endpoints.
- Develop physicochemical property assays, including solubility, logD/lipophilicity, ePSA, and related measurements.
- Develop and optimize LC-MS/MS bioanalytical methods and troubleshoot assay performance, sensitivity, selectivity, matrix effects, and reproducibility.
- Develop automated and high-throughput assay workflows to improve capacity, turnaround time, and data quality.
- Support operation and troubleshooting of MS and LC/MS instrumentation and associated laboratory automation.
- Generate high-quality experimental datasets tha...