Research Scientist I/II, Purification Sciences

JOB SUMMARY

We are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within our drug discovery team. This scientist will provide scientific and technical expertise in preparative SFC and LC purification, as well as high-throughput compound QC, supporting medicinal chemistry and high-throughput experimentation (HTE) platform.

A key focus of this role will be SFC-based purification, including method development, optimization, and application to diverse and challenging chemical matter. The ideal candidate will combine strong fundamentals in chromatographic separation science with hands-on expertise in analytical QC, instrument troubleshooting, automation, and high-throughput workflows.

This scientist will work closely with HTE, medicinal chemistry and other discovery teams to rapidly deliver purified, well-characterized compounds and high-quality analytical data, supporting an AI-driven design–make–test–learn drug discovery cycle. This position will be based out of our San Diego Headquarters.

KEY RESPONSIBILITIES

- Develop and execute small-molecule purification strategies using preparative SFC and LC, with particular emphasis on SFC method development and optimization.

- Independently solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale-up, and fraction collection.

- Develop and support high-throughput compound QC workflows using LC/MS and related analytical techniques to assess compound identity, purity, and sample quality.

- Collaborate with medicinal chemistry and HTE teams to establish fit-for-purpose purification and QC strategies and rapidly deliver high-quality compounds.

- Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting, including root-cause analysis of chromatography, fluidic...