Principal Security & Infrastructure Engineer

Profluent is seeking a Principal Security & Infrastructure Engineer to lead the company's security posture across scientific systems, lab automation environments, cloud and business infrastructure, endpoints, identity systems, and core operational workflows. This role involves designing, implementing, operating, and continuously improving technical controls, security standards, and operating practices to protect Profluent's systems and data. The position requires close collaboration with Operations, Machine Learning, Bioinformatics, and Lab Automation teams.

Key responsibilities include owning Profluent's overall security and compliance posture, leading the implementation and operational maturity work required to achieve and maintain SOC 2 and related compliance certifications, and translating customer agreements, internal policies, and compliance requirements into concrete technical and operational controls. The role also involves standardizing and hardening bioinformatics, lab informatics, and machine learning environments, defining and driving adoption of secure baseline configurations, and improving identity, access, and account lifecycle management across company systems.

The ideal candidate will have experience operating with broad ownership across infrastructure, security, and compliance in regulated, audit-conscious, or security-sensitive environments. They should have served as the most senior or primary security owner in a startup or scaling environment, possess a breadth of knowledge across infrastructure security, corporate security, IAM, endpoint management, logging and monitoring, vulnerability reduction, incident response, vendor risk, and compliance. Familiarity with Windows-based lab automation systems and experience implementing or operating against security and compliance frameworks such as SOC 2, ISO 27001, or NIST CSF are also required.

Profluent offers a high-growth opportunity with meaningful impact on the future of protein design, a competitive compensation package with equity participation, comprehensive benefits including health, dental, and vision insurance, a generous PTO policy, and professional development opportunities in a cutting-edge field at the intersection of AI and biology.