Principal Scientist, Clinical Biomarker, Immunology, Immuno-Oncology, & Hematology (Contractor)
Legend Biotech is seeking a highly motivated and innovative Principal Scientist to join their immunology and immuno-oncology clinical biomarker projects, with a dedicated focus on hematological malignancies. This role involves driving the clinical translational understanding of novel therapies in hematology, serving as the biology lead on cross-functional project teams, and developing mechanisms of action for novel cell therapies and clinical biomarker strategies.
Key responsibilities include designing, executing, and analyzing results from clinical studies to investigate the mechanisms of action for novel immuno-oncology targets in hematological indications such as AML, DLBCL, and Multiple Myeloma. The role also involves bridging discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology. Additionally, the Principal Scientist will oversee the generation and interpretation of high-dimensional molecular and cellular data, leveraging advanced single-cell technologies like scRNA-seq to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses. Collaboration with other functional teams is essential for a better understanding of mechanisms of action and fundamental immunology.
The ideal candidate will hold a Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, with the ability to initiate and lead data-driven mechanism of action studies. A minimum of 5-8 years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing immuno-oncology programs, is required. A deep understanding of immunology, particularly T-cell biology, is highly desirable, along with a profound biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow. Experience working with multi-dimensional data and extracting biological insights is highly desirable. Exceptional written and verbal communication skills are necessary, with the ability to distill complex data into clear, actionable strategic decisions.
Please note that benefits are offered exclusively to permanent full-time employees; contractors are not eligible for benefits through Legend Biotech.