Sr. Principal/Principal Scientist
Legend Biotech is seeking a highly experienced Senior Principal Scientist / Principal Scientist – Flow Cytometry to provide scientific leadership and hands-on expertise in flow cytometry to support cell and gene therapy programs from IND-enabling studies through early- and late-stage clinical development. This role is critical for ensuring scientific rigor, data quality, and strategic insight across in-house and outsourced flow cytometry activities, including assay development, validation, CRO oversight, and deep data interpretation to support translational, PK/PD, and regulatory decision-making.
Key responsibilities include leading the design, development, optimization, qualification, and validation of multicolor and spectral flow cytometry assays supporting IND-enabling animal studies and clinical trials. The role also involves providing subject-matter expertise in panel design, antibody and reagent qualification, gating strategies, and data analysis for complex immunophenotyping applications. Additionally, the scientist will conduct deep scientific review and interpretation of flow cytometry datasets to support PK/PD, mechanism-of-action, and translational insights.
The ideal candidate will have a Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related discipline with 8+ years (Principal Scientist) or 10+ years (Senior Principal Scientist) of relevant industry experience; or an M.S. with 12+ years of experience. Extensive hands-on experience with multicolor and spectral flow cytometry platforms is essential. Demonstrated experience supporting cell therapy and/or gene therapy programs, a strong understanding of bioanalytical method development, validation, and regulatory expectations, and proven ability to lead complex programs and influence cross-functional teams are also required.
The base pay range for this position is $142,146 - $186,567 USD. Additional compensation may include performance-based bonuses and/or equity, depending on the role. Benefits include medical, dental, and vision insurance, a 401(k) retirement plan with company match, paid parental leave, and a comprehensive paid time off policy. Additional voluntary benefits are also available.
Legend Biotech fosters a collaborative and innovative work environment, dedicated to developing advanced cell therapies to treat life-threatening diseases. Employees have the opportunity to work on cutting-edge therapeutics and contribute to the company's mission of delivering safe and efficacious treatments to patients worldwide.